https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Venom concentrations and clotting factor levels in a prospective cohort of Russell's viper bites with coagulopathy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27369 13), associated with low fibrinogen [median,<0.01g/L;IQR:<0.01-0.9g/L), low factor V levels [median,<5%;IQR:<5-4%], low factor VIII levels [median,40%;IQR:12-79%] and low factor X levels [median,48%; IQR:29-67%]. There were smaller reductions in factors II, IX and VII over time. All factors recovered over 48h post-antivenom. The median INR remained >3 at 6h post-antivenom but had reduced to <2, by 24h. The aPTT had also returned to close to normal (<50sec) at 24h. Factor VII, VIII and IX levels were unusually high pre-antivenom, median peak concentrations of 393%, 307% and 468% respectively. Pre-antivenom venom concentrations and the INR (r=0.20, p=0.02) and aPTT (r=0.19, p=0.03) were correlated (non-parametric Spearman analysis). Conclusions: Russell's viper coagulopathy results in prolonged aPTT, INR, low fibrinogen, factors V, VIII and X which recover over 48h. Severity of clotting abnormalities was associated with venom concentrations.]]> Wed 11 Apr 2018 11:40:46 AEST ]]> Scale reduction of a systems coagulation model with an application to modeling pharmacokinetic-pharmacodynamic data. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14545 Wed 11 Apr 2018 10:59:06 AEST ]]> Quercus robur acorn peel as a novel coagulating adsorbent for cationic dye removal from aquatic ecosystems https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30369 -1 dyes at wide ranging pH (2–10). Adsorption equilibriums were attained within 3 h. Sorbent (5 g L-1) adsorption capacity was 109.43, 115.92 and 111.85 mg g-1 for MB, AO and MG, respectively. Adsorption kinetics was described using pseudo-second-order model. Equilibrium adsorption data were interpreted by Langmuir and Freundlich isotherms. Dye removal was by coagulation-coupled adsorption. Coagulation was due to the formation of complexes between the dye molecules and OP polyphenols that led to the deposition of precipitated flocs.]]> Wed 04 Sep 2019 09:54:36 AEST ]]> A comprehensive model for the humoral coagulation network in humans https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7163 Sat 24 Mar 2018 08:34:20 AEDT ]]> Potential of Melaleuca diosmifolia as a novel, non-conventional and low-cost coagulating adsorbent for removing both cationic and anionic dyes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24802 -1 was 119.05, 126.8, 116.28 and 94.34 mg g-1 for MB, AO, MG and EB, respectively. The water extract obtained from the plant material induced fast decolourization of both categories of dyes followed by gradual flocculation, indicating its potential as a natural coagulant. Gas chromatographic analysis also indicated that the main electrostatic attraction between 1,8-cineole, 1-p-methene-8-thiol and furfural compounds of the biomaterial, and dye molecules resulted in the formation of initial supramolecular complexes which further progressed into strong aggregates, leading to precipitation of dye-biomaterial complexes. Subsequently, the overall complex mechanism of dye removal was confirmed to be a combined process of adsorption and coagulation. Consistent with the batch studies, using selected plant material in real environmental water samples also resulted in effective dye removal, highlighting its potential for use in wastewater treatment.]]> Sat 24 Mar 2018 07:15:14 AEDT ]]>